Cologuard Plus is an at-home, non-invasive multi-target stool DNA test for colorectal cancer (CRC) screening in adults 45 and older at average risk. Approved by the FDA, it detects CRC-associated DNA markers and blood in the stool, with increased accuracy and fewer false positives compared to the original Cologuard test. A positive result requires a follow-up colonoscopy to investigate further.